Yes, you can use TurboTax to prepare your first tax return. However, most people filing for the first time will not be able to NETFILE, as the CRA will not have their proper information on file.

If you are a non-resident, the CRA has started to accept those returns by fax.

You can get an address or fax number to use on this CRA webpage: https://www.canada.ca/en/revenue-agency/corporate/contact-information/where-mail-your-paper-t1-retur...