If the question is related to you and your are not mentally or physically impaired then you should choose 'No', else, if the question is about your wife having a mental or physical impairment, then you should choose 'Yes'.

Also, as per CRA "Do you support a spouse or common-law partner, or a dependant with a physical or mental impairment? The Canada caregiver credit (CCC) is a non-refundable tax credit that may be available to you" 

For more information related to the Canada Caregiver Credit, please visit the CRA

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