You are not able to claim the US. charitable donations against your Canadian income. The only exceptions are the United Nations and its agencies and registered universities outside Canada that are prescribed to be universities that have a student body that ordinarily includes students from Canada as seen in the Canada Revenue Agency (CRA) Which donations can I claim?
As per the CRA Gifts and Income Tax 2021 You can claim the eligible amount of your U.S. gifts up to 75% of the net U.S.-source income you report on your Canadian return. However, you may be able to claim the eligible amount of your gifts to U.S. organizations up to 75% of your net world income. You can do this if the gift would be allowed as a deduction under the United States Internal Revenue Code and you meet all the following conditions:
Similarly, your claim will also not be restricted to net U.S.-source income if your gift is to a U.S. college or university at which you or a member of your family is or was enrolled or if your gift is to a registered U.S. university as referenced in the list of qualified donees above.
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